Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions.
نویسندگان
چکیده
Nonracemic ethano-bridged Tröger bases are prepared using CuTC-catalyzed decompositions of diazo compounds. Excellent levels of diastereo- and enantio-control (dr and ee up to 12:1 and 95% respectively) are now obtained with aryl diazoketone precursors.
منابع مشابه
Stereoselective synthesis of configurationally stable functionalized ethano-bridged Tröger bases.
New functionalized ethano-bridged Tröger bases are readily prepared using a simple alkylation/rearrangement sequence which affords configurationally stable derivatives as single stereoisomers (de > 96%).
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 5 شماره
صفحات -
تاریخ انتشار 2012